The update is not applicable to your computerThe reason is the version of mpio.sys and msdsm.sys on your server is higher than 6.3.9600.17809. Usually, because the server installed KB3121261 already. You can ignore KB3046101.
“The Update is Not Applicable to Your Computer” When Install KB3046101
HPE 3PAR upgrading team usually sends a per-requisites before upgrading. One thing in the guide incorrect is the Windows 2012 required patch KB3046101. You may see error below when you install the path on Windows 2012 server.