Few weeks ago, I tried to standardize networking of a cluster, there were 4 VLANs for production virtual machines, I binded the VLANs on one virtual switch which had 4 physical vmnic.
Then I created 4 port groups with different VLAN ID, but for some reason virtual machines unreachable via some vmnics. Network team verified port channel was good.
I tried on several ESXi 5.0 hosts in the cluster, all had same problem, finally we found that’s a Cisco switch bug….you could find detail information and work around here.